The role of TRAIL and TRAIL receptors in atherosclerosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/568627

Funding Status
Closed

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Funded Activity Summary

The death factor, TNF-related apoptosis inducing ligand (TRAIL) is implicated in the development of atherosclerosis and can regulate cell death in the vessel wall. Recent conflicting roles for TRAIL have been described. Surprisingly, TRAIL can also stimulate cell growth. Using mice lacking TRAIL, this study will establish the function of TRAIL in models of (i) injury to the artery wall and (ii) an atherosclerotic plaque. This study will also initiate a new area of research in Australia.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $563,838.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

VSMC proliferation and survival | atherosclerosis | atherosclerotic plaque instability | cancer | cardiovascular disease | gene expression | neointimal formation | transcriptional regulation

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