Gene - environment interactions as predictors of clinical outcome in At Risk Mental State

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/567215

Funding Status
Closed

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Funded Activity Summary

The grant aims to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia. Translation to clinical practice will be facilitated by experimental and risk assessment bioinformatics research. This will enable the (i) identification of modifiable biological and cognitive mechanisms and (ii) construction of tools which can be used for the early prediction of transition to psychotic disorder and outcome monitoring. This study will identify the factors that translate genetic vulnerability to schizophrenia into overt illness. The key risk factors of stress and substance use and other environmental features will be studied as part of randomised clinical trials in young people with early symptoms who are at immediate risk of schizophrenia. This study forms part of a much larger international program of research focusing on clarifying how the vulnerability to schizophrenia develops and how it can ultimately be prevented

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2016

Funding Scheme: NHMRC Strategic Awards

Funding Amount: $1,033,620.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Psychiatry (incl. Psychotherapy)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

mental health | psychiatry | psychosis | schizophrenia | youth

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