The Role of Presenilin in Metal Homeostasis and Alzheimers Disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/567171

Funding Status
Closed

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Funded Activity Summary

Presenilin, a protein involved in Alzheimer’s disease (AD), may regulate copper and zinc levels. Copper and zinc are essential nutrients however a deficiency or excess can cause disease. Promising metal-altering AD drugs, are in various stages of clinical trial. I aim to characterize the interaction of Presenilin and metals using both mouse and cultured human cell models that are deficient in Presenilin. Understanding this interaction should lead to better drug design and treatment of AD.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2013

Funding Scheme: NHMRC Postgraduate Scholarships

Funding Amount: $86,335.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oral and maxillofacial surgery

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Copper Transport | Homeostasis | Membrane Protein | Oxidative Stress | Zinc

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