Investigating the biological significance of proteolytic prion protein processing.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/567123

Funding Status
Closed

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Funded Activity Summary

Prion diseases, including Bovine Spongiform encephalopathy (“mad cow disease”) and Creutzfeldt-Jakob Disease in humans are transmissible and fatal diseases that occur when the normal prion protein (PrPc) mis-folds and accumulates in the brain. The specific function of PrPc within a cell remains unclear, however its presence is essential for prion diseases to occur. This project aims to define how PrPc cleavage affects its biological function(s), and influences susceptibility to prion infection.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2013

Funding Scheme: Early Career Fellowships

Funding Amount: $328,558.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cell culture | prion diseases | protein characterization | proteolytic cleavage

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