NOD-like receptors and severe malaria: do inflammasomes mediate immunopathogenesis?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/567049

Funding Status
Closed

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Funded Activity Summary

Our immune system is very effective in preventing disease. But sometimes our immune cells overreact and actually make us sick. Recently, a new component of the immune system, the inflammasome, was discovered. Overreaction of the inflammasome can result in fever, inflammation, and even death. This project will investigate whether inflammasome overreaction exacerbates diseases as diverse as malaria and cancer, and whether drugs that inhibit the inflammasome can help cure these and other diseases.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: Early Career Fellowships

Funding Amount: $263,001.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cancer | Inflammation | Innate immunity | Malaria | Pattern recognition

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