Characterization ol a novel covalently cross -linked Abeta peptide dimer and its role in Alzheimers Disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566980

Funding Status
Closed

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Funded Activity Summary

Currently there are limited therapeutic treatments and no cure for Alzheimer's disease (AD). The key protein causing AD is called Abeta. Abeta peptides form dityrosine cross-linked dimers (when 2 peptides join together) and this is thought to be responsible for killing brain cells in AD. Therefore, this proposal will determine the role of Abeta dimers in relation to killing brain cells and the progression of AD through analysis of their biological and biochemical properties.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $553,236.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer's Disease | Alzheimer's disease | Alzheimer's disease and normal aging | beta amyloid | lipids | neurodegeneration | neurodegenerative and age-related diseases | neurotoxicity

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