How do red blood cells enucleate?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566919

Funding Status
Closed

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Funded Activity Summary

Removal of the nucleus from red blood cells (enucleation) is essential for proper circulation of red blood cells through the microvasculature and high haemoglobin concentration in the blood. How this fundamental process is achieved is surprisingly poorly understood. Here we propose to investigate how enucleation occurs in light of enucleation being an unusual asymmetric division. These studies are likely to lead to improvements in expansion of human red blood cells in vitro for transfusions.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $581,892.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development (Incl. Cell Division And Apoptosis)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Anemia | Blood transfusions | Diserythropoiesis | cell cycle | cell polarity | erythropoiesis

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