Targeting Post-translational Modifications in TRPV Pain Channels

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566834

Funding Status
Closed

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Funded Activity Summary

The same nerve receptor that binds the pungent component of chilli peppers (TRPV1) is an important part of our pain pathway. TRPV1 also responds to painful heat and acids. Chronic pain is an important unmet medical need and it uses the TRPV1 pathway. After activation by chilli, a feedback system in nerves inactivates TRPV1 and stops pain signalling. This feedback changes in chronic pain. This project aims to understand and exploit this feedback mechanism to find new approaches to pain therapy.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $480,127.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chronic pain | ligand-gated ion channels | molecular pharmacology | osteoarthritis | painful neuropathy | pancreatitis | protein kinases | receptor trafficking

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