The role of Gas6 and the TAM receptors in central demyelination

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566830

Funding Status
Closed

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Funded Activity Summary

In Multiple Sclerosis, oligodendrocytes, the myelin-producing cells of the brain, are damaged and myelin is lost in a process called demyelination. This process also involves the brain's immune cells, called microglia. Both cell types are influenced by a factor called Gas6, which signals through proteins called Tyro3, Axl and Mer. We have shown that levels of Gas6 can affect the severity of demyelination in mice. We plan to further study the effects of these proteins during demyelination.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $506,416.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology And Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Demyelination | Microglia | Multiple sclerosis | Neurodegenerative disease | Neuroinflammation | Oligodendrocyte

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