Amyloid precursor proteins novel role in Alzheimers disease through regulating neuronal iron homeostasis.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566827

Funding Status
Closed

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Funded Activity Summary

Our group has discovered a novel role of amyloid precursor protein (APP) in cellular iron balance. The smallest form of APP, prevalently found in the brain, is able to convert a damaging iron variety (Fe2+) into the safer Fe3+. Alternative, larger, forms of APP are found to inhibit this effect. This project will establish how APP controls iron homeostasis within brain neuronal cells and how this activity is impaired in disease, thus development a mechanism for diagnostic tests and therapeutics.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $949,667.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer's disease and normal aging | Disease mechanism | Ferroxidase activity | Neurodegeneration | Neuronal iron homeostasis | Neurotoxicity | Oxidative Stress

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