2-Methoxyestradiol analogues: prototype modulators of annexin II-dependent plasminogen activation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566776

Funding Status
Closed

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Funded Activity Summary

The enzyme system that enables us to dissolve blood clots is similar to the system that enables cancer cells to escape from the primary tumour and travel in the blood to another organ to form a secondary cancer growth. We have new results showing that some drug candidates can distinguish between these two closely related enzyme systems. We are now working to develop inhibitors that will stop cancer cells from spreading without compromising the ability to dissolve blood clots.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $369,690.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

annexin II biochemistry | anti-cancer drugs | anti-inflammatory drugs | breast cancer | cancer | cell proliferation | inflammation | plasminogen | rheumatoid arthritis | thrombolysis

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