Functions of FZD7 in the intestine and colorectal cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566679

Funding Status
Closed

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Funded Activity Summary

Wnt proteins are a family of signaling molecules that are critical for the function of normal and cancerous epithelial cells in the gut. However, the cell surface receptor that transmits Wnt signals is not known. Our research strongly implicates one Wnt receptor (FZD7). Here we test this using innovative mouse and cell line models. We wish to understand how Wnt-driven processes are activated. This knowledge will lead to novel avenues to block aberrant activation of Wnt signalling in cancer cells

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $644,761.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Sport and exercise nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Wnt-FZD signalling | cancer biology | colorectal cancer | colorectal cancer (CRC) | epithelial function | epithelium | gastroenterology | gastrointestinal tumourigenesis | intestine

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