CBS domain modulation of muscle chloride channels; molecular mechanism and physiological role.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566672

Funding Status
Closed

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Funded Activity Summary

Muscle chloride channels regulate how readily muscles are activated, particularly during muscle fatigue. Recently we have identified a feed-back mechanism linking chloride channel function to muscle acidosis and energy depletion, key factors in fatigue. Here we will investigate the molecular details of this mechanism and its role in muscle physiology and fatigue. This mechanism may present a future target for the treatment of myotonia, a condition where muscles are too readily activated.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $523,455.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chloride channel | congenital myopathies | membrane physiology | molecular mechanisms | molecular neuroscience | muscle fatigue | myotonic dystrophy | skeletal muscle fatigue

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