The Role of Huntingtin Misfolding and Oligomerization in Huntingtons Disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566640

Funding Status
Closed

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Funded Activity Summary

Mutations in the huntingtin gene cause Huntington's disease by making the gene product aggregate together into non-normal and different sized polymers. However, it is not understood how this process causes cells to die, largely because we don't understand how the abnormal forms accumulate in cells over time. We will examine where in cells the abnormal shapes accumulate and how they cause toxicity. This research will identify critically-needed therapeutic targets against Huntington's disease.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $474,329.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oral and maxillofacial surgery

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Amyloid | Huntington's Disease | Huntington's disease | Neurodegenerative disease | inherited diseases | protein characterization | protein engineering

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