Contribution of nuclear targeting of the NleE-OspZ family of proteins to Escherichia coli and Shigella virulence

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566639

Funding Status
Closed

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Funded Activity Summary

This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified new bacterial proteins that allow E. coli to manipulate the normal host cell processes involved in killing an invading bacterium. Similar proteins are also present in the closely related organism, Shigella which causes dysentary. We will determine how these proteins act by finding the host cell proteins they bind.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $542,462.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Allergy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bacterial pathogen | Host-pathogen interaction | Intestinal colonization | Shigellosis | bacterial gastroenteritis | inflammation | mucosal inflammation

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