Understanding the regulation of cell polarity in development and cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566607

Funding Status
Closed

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Funded Activity Summary

Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble and associated molecules affects normal development and promotes cancer using a combination of tissue culture studies and a newly established mouse model. These studies may provide novel targets for therapeutic intervention in cancer.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: Career Development Fellowships

Funding Amount: $428,602.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development (Incl. Cell Division And Apoptosis)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cancer and related disorders | Cell polarity | Epithelial biology | Invasion and metastasis | Wound Healing and migration

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