Molecular and cellular mechanisms of cytotoxic lymphocyte perforin

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566583

Funding Status
Closed

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Funded Activity Summary

Cytotoxic lymphocytes are immune cells, which recognise and kill virus-infected or cancer cells. Perforin is essential for the activity of cytotoxic lymphocytes. The loss of perforin function results in an inherited immune deficiency, or may lead to the development of cancer. Despite a key role of perforin, its mechanism of action and the regulation of activity are unknown. I propose to elucidate these aspects of perforin biology. This is important for understanding immune regulation in humans.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $419,223.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical chemistry (incl. diagnostics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer | cytotoxic T cell | genetic disease | immune deficiency | immunology | immunosuppression | natural killer cells | tumour immunology

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