The role of non-classical MHC class I molecules in adaptive immunity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566571

Funding Status
Closed

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Funded Activity Summary

Specialised proteins called MHC class Ia molecules (MHC-Ia) stimulate killer T cells to lyse virus infected cells. In contrast, the function of the closely related MHC-Ib is uncertain. Recent findings have demonstrated that MHC-Ib can also be recognised by T cells and this interaction is important in the control of viral infections. However, despite the similarity to MHC-Ia, it is unclear how this interaction occurs. This project aims to investigate how killer T cells recognise MHC-Ib molecules.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2015

Funding Scheme: Career Development Fellowships

Funding Amount: $443,834.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T lymphocytes | antigen presentation | major histocompatibility complex

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