Characterisation and therapeutic targeting of molecular pathways that promote breast cancer metastasis to bone

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566553

Funding Status
Closed

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Funded Activity Summary

Breast cancer that has spread to bone cannot be cured. Using the most clinically relevant model of breast cancer available we have identified that tumour cells growing in bone need to suppress immune elimination (by suppressing the Type I interferons) and invade through the bone tissue (by activation of cysteine cathepsins). Studying the functional role of these pathways will provide novel insight into the mechanisms of breast cancer spread to bone that can be augmented therapeutically.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2014

Funding Scheme: Career Development Fellowships

Funding Amount: $442,573.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone | breast cancer | immunoregulation | protease | tumour metastases

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