Characterising the physiological roles of the asparaginyl hydroxylase FIH-1 in development and disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/565515

Funding Status
Closed

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Funded Activity Summary

FIH-1 is an oxygen-sensing protein expressed in every cell. The ability for cells to detect and respond to oxygen deficiency is necessary for survival in heart disease and stroke, and is also a feature of cancer. This research aims to characterise the role FIH-1 plays in normal development and disease using mouse and tumour model systems. This research could ultimately indicate whether FIH-1 is a feasible drug target.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2014

Funding Scheme: Early Career Fellowships

Funding Amount: $274,743.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

angiogenesis | hypoxia | ischaemia | notch signalling pathway

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