Strategies for healthy osteocytes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/565372

Funding Status
Closed

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Funded Activity Summary

Osteocytes (OY) are the most abundant cell type in bone whose high density and viability are essential for healthy bone. We have found that vitamin K, vitamin D and strontium, promote human OY differentiation. We will test these in novel models of human OY differentiation and survival, and in animal models of bone loss associated with vitamin D deficiency, menopause and glucocorticoid treatment. Our work will lead to a better understanding of human OY and give a new approach to treat osteoporosis.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $511,294.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Orthopaedics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Age-related bone loss | Bone loss due to glucocorticoid use | Bone loss due to loss of oestrogen | Bone remodelling | Human osteocyte biology | Osteoblast | Osteoporosis | mechanism of action of anabolic treatments

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