Functions of ASCIZ in the repair of accidental and programmed DNA base damage

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/559020

Funding Status
Closed

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Funded Activity Summary

Every cell in the body encounters approximately 10,000 DNA base lesions per day. If not accurately repaired, this DNA damage may give rise to cancer. We have discovered a new protein called ASCIZ that is involved in the cellular response to base damage. We believe that ASCIZ functions by promoting the most efficient way to repair damaged DNA bases. We will investigate this hypothesis using cells that lack the ASCIZ gene, and also test if defective ASCIZ leads to increased cancer.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $613,060.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA damage | DNA repair | cancer biology | cancer chemotherapeutic agents | cancer chemotherapy | cancer susceptibility | carcinogenesis | lymphoma | mutagenesis

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