Identification of orphan F-box helicase substrates and their role in genomic stability and life extension.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/552497

Funding Status
Closed

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Funded Activity Summary

Within each cell proteins are synthesised and destroyed with delicate control to ensure the cell functions appropriately. Excess proteins are removed by specific degradation pathways, which are often misregulated in cancer. This project aims to further our understanding of misregulated protein degradation in cancer. The knowledge gained will assist with the development of cancer targeting drugs specific to protein degradation pathways that become misregulated in tumour formation.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2013

Funding Scheme: Early Career Fellowships

Funding Amount: $281,684.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cell cycle | DNA damage | F-box proteins | Ubiquitin-mediated proteolysis

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