Macrophage mineralocorticoid receptor signalling regulates systolic blood pressure and cardiovascular remodelling.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/550903

Funding Status
Closed

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Funded Activity Summary

Drugs that block the mineralocorticoid receptor (MR), which responds to adrenal hormones, protect against heart disease and hypertension. We have shown that this effect is in part due to MR blockade in inflammatory cells. This novel finding is being explored further to understand the precise role of the MR in inflammatory cells in normal physiology and in disease. An understanding of the role of the MR in different tissues will enable development of tissue specific treatments for heart disease.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $506,618.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Hypertension | cardiac failure | cardiovascular disease | hypertension | macrophage activation | mineralocorticoid receptor signalling | renovascular disease | vascular inflammation

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