Neural Crest Stem Cell Therapy for Absence of Intestinal Nerves in Hirschsprungs Disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/546473

Funding Status
Closed

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Funded Activity Summary

Hirschsprung's disease is acommon birth defect caused by failure of nerve cells to get into the colon. This results in intractable often fatal constipation. Current treatment is surgical removal of the affected colon soon after birth but often problems persist. These nerves might be rebuilt using nerve stem cells, but not all stem cells have this capacity. And is not known if this can be achieved after birth: This project will define which stem cell populations to use and in what age of bowel.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $504,377.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Sport and exercise nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Hirschsprung's Disease | abnormal development | colon | colonic dysmotility in children | murine models | neural crest | neural stem cell | stem cell therapy

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