Pathways involved in the insulin-like growth factor (IGF)-independent actions of IGF binding protein-6

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/546016

Funding Status
Closed

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Funded Activity Summary

Insulin-like growth factors (IGFs) are important proteins that regulate growth. When not regulated properly, diseases such as cancer can occur. A family of IGF binding proteins regulates IGFs. IGFBPs may inhibit IGFs and we have shown that one of them, IGFBP-6, decreases growth of some experimental cancers. As well as regulating IGFs, some IGFBPs alter cell behaviour independently of IGFs, and we found that IGFBP-6 stimulates cell movement in this way. We will now determine how this happens.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $550,725.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

binding protein | cancer | cell migration | endocrine therapy | growth factor regulation | growth factors | insulin-like growth factors | protein-protein interaction | signalling pathways

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