Characterisation of antigenic variation of Neisserial cell surface adhesins, and their role in infection

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/546003

Funding Status
Closed

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Funded Activity Summary

A group of bacteria called Neisseria cause human-specific infections. They produce two types of surface proteins termed adhesins, which allow the bacteria to adhere to, and invade, human cells. There is circumstantial evidence to suggest the bacteria can rapidly vary the structure of these adhesins, even within a single infection. This project will determine whether, and how, this variation is occurring, and what effect it has on the ability of the bacteria to cause disease.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $556,983.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Allergy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

adherence | antigenic variation | gene regulation | gonorrhoea | meningitis | meningococcal disease | neisseria gonorrhoeae | neisseria meningitidis | pelvic inflammatory disease | virulence

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