Melanocortin Regulation of Reproduction

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/545918

Funding Status
Closed

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Funded Activity Summary

Reproduction is controlled by the brain through the hormone gonadotropin releasing hormone (GnRH). Leptin from fat acts on the brain to 'inform' GnRH cells of metabolic state; low levels signal lack of energy stores and suppress reproduction. Leptin treatment of lean individuals restores reproductive function, but the mechanism is not clear. Our data implicate the melanocortins as a means of transmitting information on metabolic state to GnRH cells and the project investigates this pathway.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $591,967.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Adiposity and Obesity | Eating Disorders | Hypothalamus | Infertility | Neuroendocrinology | Neuropeptides | Neurotransmission | POMC | Proteomics | Reproductive Dysfunction and Fertility Control

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