The role of the ABCA12 transporter in epidermal lipid homeostasis and atherosclerosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/545906

Funding Status
Closed

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Funded Activity Summary

We have shown that a protein called Abca12 can control the transport of lipids in our bodies. If the function of this gene is attenuated both human and mice develop severe skin disease. Our preliminary results indicate the Abca12 protein regulates cholesterol transport in particular, and this grant will investigate how this might affect normal skin function and contribute to the heart disease atherosclerosis, one of the most common causes of death in the western world.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $516,401.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Dental therapeutics pharmacology and toxicology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Atherosclerosis | Cholesterol transport | Harlequin and other Ichthyoses | Lipid Homeostasis in the skin and vessels | Skin disease and barrier function

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