Regulation of insulin signalling and glucose homeostasis by protein tyrosine phosphatases

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/545846

Funding Status
Closed

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Funded Activity Summary

A common feature of type 2 diabetes is high blood glucose due to peripheral insulin resistance. Protein tyrosine phosphatases (PTPs) that antagonise insulin signalling might be important targets for therapeutic intervention in type 2 diabetes; inhibition of specific PTPs may allow for enhanced IR signalling to alleviate insulin resistance. This proposal will examine the roles of PTPs and in particular TCPTP in insulin signalling and glucose homeostasis.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $542,462.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutritional science

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cell signalling | Cre-lox knocout mice | Diabetes | Diabetes (type 2) | Endocrinology | Improved insulin sensitivity | Insulin resistance | Protein tyrosine phosphatase | Signalling

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