Novel microtubule association sequences from rabies virus; subversion of antiviral responses and use in drug delivery

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/545838

Funding Status
Closed

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Funded Activity Summary

The P-protein from rabies virus (RV) has distinct sequences that enable it to exploit the cellular skeleton (cytoskeleton) to localise efficiently in the host cell nucleus to exert pathogenic effects, or to perturb the cytoskeleton and thereby impair the host cell anti-viral response and immune response generally. We aim to characterise these properties in detail, demonstrate their importance to RV pathogenicity, and test the utility of the P-protein sequences in drug delivery.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $529,632.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antiviral therapies | dynein light chain association sequence | gene therapy | intracellular transport | microtubular cytoskeleton | nuclear drug delivery | rabies virus | rabies virus P-protein

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