Manipulation of Haematopoietic stem cell niches to improve their clinical use

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/543706

Funding Status
Closed

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Funded Activity Summary

Haematopoietic stem cells (HSC) reside in adult bone marrow (BM) and make all blood and immune cells. HSCs can be damaged by chemotherapy leading to blood and BM failure. We have identified an adhesion molecule in the BM which regulates HSC behaviour. We anticipate that inhibiting this molecule will i) help minimise HSC damage during chemotherapy and ii) enhance the success of BM transplantation.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $434,883.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Adhesion molecules | Bone marrow | Bone marrow reconstitution | Bone marrow transplant | Haematological disorders | Haematopoiesis | Haematopoietic stem cell niche | Haematopoietic stem cell transplantation | Leukocyte trafficking | Stem cell therapy

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