Structural investigations of bacterial evasion of IgA mucosal and systemic immunity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/543317

Funding Status
Closed

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Funded Activity Summary

Nose, throat and skin infections are often caused by streptococcal and staphylococcal bacteria, known as Strep Throat and Golden Staph. Infections can be life-threatening in newborns, the elderly or individuals with weak immune systems. These bacteria make proteins bind and inactivate immune proteins. Our research examines the structural basis for bacterial interactions with a key immune system protein (an antibody called IgA) and may lead to new prevention and treatment strategies.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $488,812.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bacterial binding proteins | Bacterial infection prevention and treatment | Bacterial virulence factors | Crystallography and small-angle scattering | IgA mediated immunity | IgA mucosal and systemic immunity | Immune evasion | Mucosal bacterial pathogens | Streptococcal and Staphylococcal infections | Structural biology

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