Role of the hepatitis C virus glycoprotein E2 variable regions in viral entry and antibody mediated neutralization.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/543113

Funding Status
Closed

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Funded Activity Summary

The first stage of Hepatitis C Virus replication involves attaching to liver cells. This study is aimed at understanding how the virus attaches to liver cells and how antibodies raised during infection, block this interaction. In addition, this study aims to examine how the virus modulates its structure to evade the immne system, allowing the virus to establish chronic infections. The results of this study will guide future vaccine design for HCV.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $542,462.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Antibody | Hepatitis C Virus | acute hepatitis | chronic disease caused by hepatitis C virus infection | development of HCV vaccine | envelope glycoprotein | prevention of infectious disease | viral fusion | viral hepatitis

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