Envelope glycoprotein determinants underlying cytopathicity of CCR5-restricted human immunodeficiency virus type 1

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/543103

Funding Status
Closed

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Funded Activity Summary

HIV weakens the immune system causing AIDS, but the mechanism by which HIV does this are poorly understood. This proposal aims to define these mechanisms. We expect that HIV evolves in infected people, becoming better able to infect and kill cells of the immune system, and that this results from specific genetic changes in the virus. This study will contribute to a greater understanding of how HIV causes AIDS, which is necessary for the development of new drugs to treat HIV infection.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: Career Development Fellowships

Funding Amount: $428,602.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Envelope glycoprotein | HIV-AIDS | Retroviral receptors | Viral pathogenesis | Virus entry and replication

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