Dissecting BAFF Receptor Signals: Key Mediators of B-Lymphocyte Survival and Autoimmune Disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/541951

Funding Status
Closed

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Funded Activity Summary

B-Cells of the immune system need a growth factor named 'BAFF' to grow and survive. Elevated levels of BAFF have been detected in patients suffering from autoimmune diseases like lupus and arthritis, and B-Cell cancers like myeloma. This study will determine the identity of the chemical messages that BAFF sends to B-Cells, and how these facilitate B-Cell growth and survival. This will provide a framework for the design of targeted drug therapies that reduce the severity of BAFF related diseases.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2014

Funding Scheme: Early Career Fellowships

Funding Amount: $376,165.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

B-Lymphocyte survival | BAFF, APRIL and their receptors | TNF Receptor | cytokine signaling | signal transduction

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