Molecular dissection of cytokine-mediated regulation of human B-cell differentiation.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/536000

Funding Status
Closed

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Funded Activity Summary

Interleukin 21 is a molecule which activates B cells. Defects in this pathway cause immunodeficiency where individuals cannot make antibodies, while constant activation has been reported in mouse models of autoimmunity. Examining these pathways will shed light on the causes of human immune disease, and may reveal molecules that could be targeted for the treatment of immunodeficiency and autoimmunity. Amplification of normal immune responses could lead to the development of improved vaccines.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2014

Funding Scheme: Postgraduate Scholarships

Funding Amount: $119,314.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical microbiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

B lymphocyte | cytokine | immunoglobulin | lymphocyte differentiation

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