The characterisation of Deubiquitinating Enzyme A (DUBA) in the control of innate and adaptive immune signalling.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/535975

Funding Status
Closed

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Funded Activity Summary

In response to viruses, the immune system produces interferons. Interferons fight infections but can also contribute to autoimmune diseases, where the body mistakenly attacks itself. Production of interferons is regulated by DUBA. Thus DUBA is an attractive target for therapies against viruses or autoimmune diseases. To achieve this, it is important to understand not only the mechanism of action of DUBA, but also what other roles DUBA may play in the immune system. We can study these in mice.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2015

Funding Scheme: Early Career Fellowships

Funding Amount: $396,041.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Immunology | Pattern recognition receptors | Signalling | Tumour necrosis factor receptor | Ubiquitin

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