The role of Interleukin-21 in the pathogenesis of autoimmune diabetes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/535934

Funding Status
Closed

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Funded Activity Summary

Interleukin-21 (IL-21) is a soluble protein that is produced by cells enabling them to communicate with other cells. IL-21 helps cells to clear viruses and bacteria from the body. However, our studies show that IL-21 also generates T cells that destroy beta cells and cause diabetes. IL-21 is produced at abnormally high levels in an important murine model of spontaneous type-1 diabetes (T1D) and if we block IL-21 we prevent diabetes. This projects' aims assess IL-21 as therapeutic target for T1D.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $489,060.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Emergency medicine

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

autoimmunity | costimulation | insulitis | interleukin-21 | islet transplantation | predictive marker | therapeutic intervention for protection of beta cell mass | type-1 diabetes (T1D)

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