Non-neuronal ATP: regulation of release and action in the bladder

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/527502

Funding Status
Closed

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Funded Activity Summary

Incontinence disorders are costly and debilitating. How the bladder signals the normal sensation of fullness as well as the urgent need to void urine (urgency) is still not fully understood. The signaling molecule ATP is released during bladder stretch. Using animal and human bladder, we will study how the bladder lining is involved in this signaling process, by measuring how bladder chemicals interact with stretch to modulate ATP release, and how ATP can influence nerve impulses to the brain.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $451,553.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bladder urothelium | human bladder dysfunction | management of urinary tract dysfunction in elderly women | overactive bladder - detrusor overactivity | painful bladder syndrome | purinergic mechanisms | tachykinin receptors | urgency | urinary urge incontinence | vanilloid receptors

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