Antioxidant glutathione peroxidase (GPx) mimetics and atherosclerosis: a role for targeted antioxidant therapy.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/526656

Funding Status
Closed

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Funded Activity Summary

This proposal investigates the use of antioxidant therapy, targeted at increasing the function of the body's important antioxidant enzyme GPx1, to reduce atherosclerosis both in a non-diabetic and diabetic setting. Strong clinical evidence and our recently published data support an important role for GPx1 in limiting atherosclerosis. We will now investigate the molecular mechanisms involved in mediating these effects and whether compounds that mimic GPx1 function reduce atherosclerosis.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $358,319.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antioxidant enzyme | antioxidants | atherosclerosis | diabetes | oxidative stress | vascular biology | vascular disease

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