Platelet-Activating and Proinflammatory Effects of Proteins Secreted by Staphylococcus aureus

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/526626

Funding Status
Closed

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Funded Activity Summary

Skin or other Staphylococcus aureus (SA, golden Staph.) infections are common in Aboriginal Australians. We address the question whether atherosclerotic disease is accelerated by this bacterial infection. We will investigate whether a class of newly described toxins secreted by SA activates blood cells and leads to clot formation and potentially heart attack. We will evaluate plasma samples from cardiac patients and Aboriginal Austr. and will develop and test therapeutics in vitro and in mice.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $515,986.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Aboriginal health | antibodies | atherosclerosis | glycoproteins | inflammation | monocytes | platelets | staphylococcus aureus | stapylococcus aureus | thrombosis

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