A novel cardiac inotropic mechanism that provides functional benefit

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/526622

Funding Status
Closed

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Funded Activity Summary

Patients with heart failure are often treated with an inotropic agent to increase the force of the heart's contraction and thus improve quality of life for these patients. Most inotropic agents have deleterious effects that limit their usefullness. Mice that have increased alpha1-A receptor expression in their hearts have heightened contactility that is not associated with hypertrophy or arrhythmias. We will use microarray, and si-RNA delivery and signalling studies to identify the mechanism.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $413,936.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Ageing | Cardiomyopathy | Heart Failure | inotropic agents | signal transduction | transgenic animals

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