Obesity, insulin resistance and hepatocarcinogenesis: metabolic mediators and molecular mechanisms

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/525473

Funding Status
Closed

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Funded Activity Summary

Liver cancer (or hepatocellular carcinoma, HCC) is the 3rd most common cause of cancer death, with the incidence in Australia increasing. Recently, it has been shown that obesity, diabetes and fatty liver disease can lead to HCC; this project will explore how metabolic diseases promote HCC. The role of insulin and fatty acids in promoting DNA damage and cell growth will be examined. Understanding how metabolic disease increases HCC risk will improve prevention strategies and possible treatments.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2013

Funding Scheme: Early Career Fellowships

Funding Amount: $199,485.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

DNA damage | insulin resistance | leptin | liver cancer | obesity

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