The evaluation of gamma-glutamylcyclotransferase as a novel target for cancer therapy and diagnosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/525458

Funding Status
Closed

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Funded Activity Summary

Gamma glutamylcyclotransferase (GGCT) plays a pivotal role in regulating the synthesis of glutathione, a compound that is essential for life and regulates many intracellular processes. Several recent studies have shown that GGCT is highly expressed in cancer cells . This study will determine if GGCT is a target for cancer chemotherapy or if it can be used for cancer diagnosis. This study may also provide a new treatment for patients with glutathione synthetase deficiency.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $433,900.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry and metabolomics not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

5-oxoprolinuria | Cancer | Glutathione metabolism | Glutathione synthetase deficiency | New cancer drug target | gamma glutamyl cyclotransferase

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