Enhancement of mucosal immunity and CTL avidity against HIV-1

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/525431

Funding Status
Closed

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Funded Activity Summary

Production of strong antiviral immunity at the local mucosa (genito-rectal track) is essential for protection against HIV-AIDS. We believe that expression of small hormone-like molecules known as Th2 cytokines IL-4-IL-13 negatively influence the generation of protective immunity against HIV. Thus we aim to counteract these effects by co-expressing proteins known as chemokines together with vaccine antigens to improve the quality of mucosal vaccine immunity.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $553,070.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

CD8 T cell avidity | HIV-AIDS | Pox virus prime-boost vaccines | T cell immunity | cytokines -chemokines | mucosal infection and vaccine immunity | mucosal vaccines and immunity

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