Targeting Protein Synthesis in the Apicoplast and Cytoplasm of Plasmodium

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/520700

Funding Status
Closed

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Funded Activity Summary

New antimalarial drugs are desperately needed. Protein synthesis in Plasmodium falciparum is a validated target for existing drugs and is a promising target for new drugs. This project brings together malaria biologists with chemists and computer scientists to explore this promising field. We will apply modern methods of drug target characterisation to find the most promising enzyme targets involved in protein synthesis and to identify inhibitors as leads for developing antimalarial therapies. Australian researchers involved in this project will provide expertise in bioinformatic prioritisation of Plasmodium drug targets from the aminoacyl tRNA synthetase family of enzymes. We will use structural modelling and docking experiments to identify promising antimalarial inhibitors, and will optimise assays to assess the effects of these inhibitors. We will also apply modern molecular biology tools to validate these enzymes as anti-malarial drug targets.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Strategic Awards

Funding Amount: $453,768.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Humoural immunology and immunochemistry

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Antimalarial | antiparasitic | infection disease | malaria

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