Directed molecular evolution of G protein-coupled receptors for stable and functional expression in Escherichia coli

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/520309

Funding Status
Closed

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Funded Activity Summary

Approximately half of all prescription drugs on the market act on G protein coupled receptors (GPCRs). The mechanisms underlying GPCR function are mainly unknown due to a lack of structural information. No solved structures exist for any of the estimated 800 human GPCRs, making it difficult to design new drugs. By applying advanced protein engineering techniques I aim to produce human GPCRs in bacteria to ultimately acquire structural information, which will enable novel drug development.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2013

Funding Scheme: Early Career Fellowships

Funding Amount: $383,479.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G-protein coupled receptors | Protein Structure | Protein engineering | Protein expression

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