Investigating the involvement of human derived astrocytes and motor neurons in the pathology of motor neuron disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/520165

Funding Status
Closed

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Funded Activity Summary

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease, which results in the death of nerves that innervate muscle, known as motor neurons. Recent studies using mouse ALS models showed that certain cells that normally support motor neurons may be directly contributing to their death in ALS. We propose to derive ALS-diseased human cells and investigate how these cells may react in ‘normal’ tissue. These studies are clinically relevant in understanding ALS pathological processes.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: Early Career Fellowships

Funding Amount: $287,321.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

motor neuron disease | neuron-glia interactions | neuronal death | stem cells | superoxide dismutase

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