Phasevarions of pathogenic Neisseria

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/519704

Funding Status
Closed

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Funded Activity Summary

Certain bacterial DNA repeats are prone to hyper mutation. Genes with these repeats, Contingency genes, are randomly switched on and off. This process, phase variation , generates diversity in a population. Recently we described a new class of contingency gene that methylates DNA. On-off switching of this gene leads to random switching of multiple genes; the phasevarion . We will define the impact of this system in bacteria causing meningitis and STDs.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $557,939.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Infectious Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Disseminated gonococcal infection | Fulminant Meningococcal Septicaemia | Gonorrhea | Meningitis | Meningococcal Disease | Neisseria gonorrhoeae | Neisseria meningitis | methyltransferase | phase variation

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